Contributor: Jennifer Huang

Data from over 3 million US Veterans explored connections between HF and kidney disease, common co-morbid players. The data showed that having HF increases the risk of developing kidney disease and accelerates the process.

Hemodynamic changes (low cardiac output and increased renal venous pressure), neurohormonal changes (activation of the sympathetic nervous and renin angiotensin systems), increased oxidative stress, and inflammatory activation are likely to blame. Additionally, elevated renal G-Protein Coupled Receptor – G protein – was associated with renal tissue damage, fibrosis, and inflammation.

Everything should be taken with a grain (<2 gm) of salt. The limitations of this study are its observational nature, more than 90% male participants, and use of ICD-9 codes to define HF with no differentiation between HFpEF and HFrEF.

In a heartbeat… Having HF is associated with future development of kidney disease through various mechanisms. As such, patients with known HF (HFpEF or HFrEF) may benefit from aggressive renoprotective measures.

Study Link: Relaxation and the Role of Calcium in Isolated Contracting Myocardium From Patients With Hypertensive Heart Disease and Heart Failure With Preserved Ejection Fraction