Contributor: Jennifer Huang

Does concentric left ventricular hypertrophy (LVH) progress to dilated cardiomyopathy (DCM)? It may not be as common as we previously thought and the transition may occur over decades.

1,386 participants of the Dallas Heart Study without baseline LV dilation were included. Ten percent of the participants had baseline LVH (7.2 g/mL0.67  for men and 5.8 g/mL0.67 for women). The study population had a mean age of 44 years, 57% women and 43% black patients. Of note, patients that developed cardiovascular disease during the study period (MI, CABG, PCI, stroke or HF) were not included in the final cohort of 1282. Baseline and follow up cardiac magnetic resonance imaging was performed a median of 7 years after baseline imaging.

An increase in LVEDV was significantly (p<0.01) more common among patients with baseline LVH. However, the change in LVEDV was small (1ml in those with LVH and -2ml in those without) over the 7 year period. Overall, the progression to DCM was 3% in those with LVH and 2% in those without LVH.

In a heartbeat… LVH hearts tend to slightly increase LVEDV over time, but progression to DCM remains a rare phenomenon, at least in the Dallas Heart Study cohort.

Study Link: Association of Concentric Left Ventricular Hypertrophy With Subsequent Change in Left Ventricular End-Diastolic Volume: The Dallas Heart Study