American Heart Association

Increased Mortality in Patients with Respiratory Failure Before or After Durable LVAD Implantation

Contributor: Sadaf Sharfaei

Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Study Link: Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Decoupling between dPAP and PCWP predicts mortality and HF readmission among CF-LVAD patients

Contributor: Elise Vo

Decoupling of diastolic pulmonary artery pressure and PCWP (greater than 5 mmHg difference) during ramp testing in continuous flow LVAD patients is a significant predictor for HF hospitalization and all-cause mortality. This decoupling is also represented as the diastolic pressure gradient (dPAP-PCWP). dPAP and PCWP decoupling (increased DPG) may indicate intrinsic pulmonary vascular pathology and associated right ventricular strain.