American Heart Association

outcomes research

Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients

Contributor: Ike Chinyere

Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients
REVIVAL (Registry Evaluation of Vital Information for VADs in Ambulatory Life)

Study Link: Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients

Increased Mortality in Patients with Respiratory Failure Before or After Durable LVAD Implantation

Contributor: Sadaf Sharfaei

Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Study Link: Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Superior Survival in Women with HFpEF but Worse HF Symptoms & Quality of Life

Contributor: Sadaf Sharfaei

Sex-Related Differences in Heart Failure With Preserved Ejection Fraction

Study Link: Sex-Related Differences in Heart Failure With Preserved Ejection Fraction

VITALITY-HFpEF: Designed to test the hypothesis that vericiguat may improve physical functioning in patients with HFpEF

Contributor: Emily Cendrowski

VITALITY-HFPEF is a trial underway which will evaluate the efficacy of vericiguat in HFpEF patients by using the KCCQ-PLS (Kansas City Cardiomyopathy Questionnaire Physical Limitation Score) as a primary endpoint. The choice of this primary endpoint will make it the first HF trial utilizing a quality of life, patient-reported outcome (PRO) as a primary endpoint. There remains a need for medications which improve mortality and functional status for patients with HFpEF. An ongoing area of research involves the cyclic guanosine monophosphate (cGMP) pathway.

Visual Abstract: Validity of Performance and Outcome Measures for Heart Failure

Contributor: Ike Chinyere

Validity of Performance and Outcome Measures for Heart Failure

Study Link: Validity of Performance and Outcome Measures for Heart Failure