American Heart Association

Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients

Contributor: Ike Chinyere

Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients
REVIVAL (Registry Evaluation of Vital Information for VADs in Ambulatory Life)

Study Link: Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients

Increased Mortality in Patients with Respiratory Failure Before or After Durable LVAD Implantation

Contributor: Sadaf Sharfaei

Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Study Link: Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Visual Abstract: Endothelial Function with Continuous-Flow LVADs

Contributors: Ike Chinyere and Chase Stroud, MD

Effect of Continuous-Flow Left Ventricular Assist Device Support on Coronary Artery Endothelial Function in Ischemic and Nonischemic Cardiomyopathy

Study Link: Effect of Continuous-Flow Left Ventricular Assist Device Support on Coronary Artery Endothelial Function in Ischemic and Nonischemic Cardiomyopathy

Clinical and In Vitro Evidence that LVAD-Induced Von Willebrand Factor Degradation May Alter Angiogenesis

Contributor: Darien Allen

GI bleeds in continuous-flow left ventricular assist device (CF-LVAD) patients are an increasing problem. Bartoli et al posit a two-hit hypothesis to explain the increased risk of mucosal bleeds in this population:

Hit 1: CF-LVAD-induced shear stress activates von Willebrand factor (VWF) multimers leading to enzymatic and mechanical degradation into variably sized fragments and acquired VWF deficiency. CF-LVAD induced VWF deficiency reduces VWF-collagen and VWF-platelet binding resulting in increased risk of mucosal bleeding.
Hit 2: Higher circulating concentrations of VWF fragments lead to altered angiogenesis and likely contribute to the development of angiodysplasia.

Early right ventricular assist device utilization in patients undergoing continuous-flow left ventricular assist device implantation: Insight from INTERMACS

Contributor: Steven Stroud

Frustrated by limited, single small center risk scores for RV failure? Kiernan and colleagues analyzed the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) to identify factors associated with RV failure following continuous flow left ventricular assist device (CF-LVAD) support.