American Heart Association

mechanical circulatory support

Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients

Contributor: Ike Chinyere

Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients
REVIVAL (Registry Evaluation of Vital Information for VADs in Ambulatory Life)

Study Link: Comorbid Conditions and Health-Related Quality of Life in Ambulatory Heart Failure Patients

Increased Mortality in Patients with Respiratory Failure Before or After Durable LVAD Implantation

Contributor: Sadaf Sharfaei

Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Study Link: Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure

Visual Abstract: Endothelial Function with Continuous-Flow LVADs

Contributors: Ike Chinyere and Chase Stroud, MD

Effect of Continuous-Flow Left Ventricular Assist Device Support on Coronary Artery Endothelial Function in Ischemic and Nonischemic Cardiomyopathy

Study Link: Effect of Continuous-Flow Left Ventricular Assist Device Support on Coronary Artery Endothelial Function in Ischemic and Nonischemic Cardiomyopathy

Hemodynamic Ramp Testing For More Accurate HVAD Tuning

Contributors: Ike Chinyere and Michela Brambatti

Impact of Hemodynamic Ramp Test-Guided HVAD Speed and Medication Adjustments on Clinical Outcomes The RAMP-IT-UP Multicenter Study

Study Link: Impact of Hemodynamic Ramp Test-Guided HVAD Speed and Medication Adjustments on Clinical Outcomes: The RAMP-IT-UP Multicenter Study

Clinical and In Vitro Evidence that LVAD-Induced Von Willebrand Factor Degradation May Alter Angiogenesis

Contributor: Darien Allen

GI bleeds in continuous-flow left ventricular assist device (CF-LVAD) patients are an increasing problem. Bartoli et al posit a two-hit hypothesis to explain the increased risk of mucosal bleeds in this population:

Hit 1: CF-LVAD-induced shear stress activates von Willebrand factor (VWF) multimers leading to enzymatic and mechanical degradation into variably sized fragments and acquired VWF deficiency. CF-LVAD induced VWF deficiency reduces VWF-collagen and VWF-platelet binding resulting in increased risk of mucosal bleeding.
Hit 2: Higher circulating concentrations of VWF fragments lead to altered angiogenesis and likely contribute to the development of angiodysplasia.