American Heart Association

basic studies

Progenitor cells are decreased in heart failure and specific to HF type

Contributor: Mat Bull

Do progenitor cells matter for patients with HF? First, what is a progenitor cell? A progenitor cell is a stem cell that has potential to differentiate into multiple different cell types. Progenitor cells are classified by cluster of differentiation surface markers, which act as receptors and ligands to their target tissue. CD34+ progenitor cells have been shown to play a role in vascular and myocardial regeneration and in this article are shown to be an important biomarker in heart failure.

Cathespin D–mediated autophagosome flux prevents cardiac remodeling and restrictive cardiomyopathy

Contributor: Steven Stroud

How does the heart clean up after a myocardial infarction? Autophagy. Wong et al identified the role of Cathespin D as a regulator of cardiac remodeling.

First, what is autophagy? Autophagy is derived from the Greek “auto” meaning self and “phagy” meaning eating. Pay close attention, as it is soon to be a familiar term in our field. Exciting new basic and translational research will be presented in CircHF in the coming months.