American Heart Association

Visual Abstract: Spironolactone Reduces Albuminuria in HFpEF

Contributor: Ike Chinyere

Prognostic Value of Albuminuria and Influence of Spironolactone in Heart Failure With Preserved Ejection Fraction The TOPCAT Trial

Study Link: Prognostic Value of Albuminuria and Influence of Spironolactone in Heart Failure With Preserved Ejection Fraction: The TOPCAT Trial

Visual Abstract: Validity of Performance and Outcome Measures for Heart Failure

Contributor: Ike Chinyere

Validity of Performance and Outcome Measures for Heart Failure

Study Link: Validity of Performance and Outcome Measures for Heart Failure

Visual Abstract: Factors Associated with Persistently Low Sacubitril/Valsartan Use

Contributors: Ike Chinyere and Steven Stroud

Patient, Provider, and Practice Characteristics Associated With Sacubitril/Valsartan Use in the United States

Study Link: Patient, Provider, and Practice Characteristics Associated With Sacubitril/Valsartan Use in the United States

Visual Abstract: CF-LVAD Patients on Digoxin Have Less Angiodysplasial GI Bleeding

Contributor: Ike Chinyere

Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices

Study Link: Digoxin Is Associated With a Decreased Incidence of Angiodysplasia-Related Gastrointestinal Bleeding in Patients With Continuous-Flow Left Ventricular Assist Devices

Female HCM patients with obstructive physiology undergo myectomy later and have worse diastolic dysfunction but more compliant titin

Contributor: Nick Hawkes

Hypertrophic Cardiomyopathy (HCM) is a genetic condition characterized by unexplained left ventricular hypertrophy often with a wall thickness of greater than or equal to 15mm. it often disproportionately affects the septum and can lead to development of left ventricular outflow obstruction (LVOTO). Myectomy is a targeted surgical reduction in LV mass — thereby reducing LVOTO. Nijenkamp et al analyzed samples obtained during myectomy as well as pre-myectomy echocardiographic markers of diastolic dysfunction in 71 HCM patients. The authors also compared control myocardium to HCM. In this study, female HCM patients presented later, had a higher degree of diastolic dysfunction, a higher amount of fibrosis, more compliant titin, and greater septal thickness when indexed to body surface area (IVSi) compared to males.