Elizabeth M. Aradine, DO
Kapoor A, Si K, Yu AYX, Lanctot KL, Herrmann N, Murray BJ, et al. Younger Age and Depressive Symptoms Predict High Risk of Generalized Anxiety After Stroke and Transient Ischemic Attack. Stroke. 2019;50:2359-2363.
Poststroke anxiety is not uncommon and can negatively affect quality of life. The relationship between stroke and anxiety has been demonstrated, but few studies have included young patients. Furthermore, the presence of premorbid depression is a predictor of poststroke anxiety; however, it is unknown if the absence of depression is a protector against poststroke anxiety. The authors of this study sought to elucidate the effect of age and depression on poststroke or TIA anxiety.
This study was conducted using registry data from the DOC Feasibility Study, a prospective longitudinal cohort of stroke, TIA, and non-stroke patients. Only those with a diagnosis of stroke or TIA were included for analysis in this study. Aphasic patients were excluded. Anxiety was assessed using the Generalized Anxiety Disorder 7-item (GAD-7) scale with a score ≥10 indicating moderate to severe symptoms. Depression was assessed using the Epidemiological Studies Depression Scale (CES-D) with ≥16 indicating moderate to severe symptoms.
257 patients were included, 125 with stroke and 133 with a TIA. 21.7% of patients had a GAD-7 score of ≥10. 25.2% had CES-D scores ≥16. Young patients (<50 years old) and those with CES-D scores ≥16 were more likely to have anxiety after a TIA or stroke. See Figure.