Lin Kooi Ong, PhD
Yu SP, Tung JK, Wei ZZ, Chen D, Berglund K, Zhong W, et al. Optochemogenetic Stimulation of Transplanted iPS-NPCs Enhances Neuronal Repair and Functional Recovery after Ischemic Stroke. J Neurosci. 2019; 39:6571-6594.
Stem cell-based therapies certainly do hold potential as therapeutic tools for promoting brain repair and functional recovery after stroke. However, there are several fundamental issues to be considered, such as whether the transplanted stem cells can survive, differentiate and form meaningful connections with the host brain. This recent article by Yu and colleagues described an innovative method called “optochemogenetic” to promote the integration of transplanted stem cells into a stroked (or injured) brain that could lead to neuronal restoration and functional recovery. The team genetically introduced luminopsin 3 into neural progenitor cells that have been derived from induced pluripotent stem cells, which they called LMO3-iPS-NPCs. Luminopsin 3 is a bioluminescent protein that can be simulated by either a physical light source or light-emitting molecule such as coelenterazine.