Isabella Canavero, MD
Kamin Mukaz D, Zakai NA, Cruz-Flores S, McCullough LD, Cushman M. Identifying Genetic and Biological Determinants of Race-Ethnic Disparities in Stroke in the United States. Stroke. 2020;51:3417–3424.*
The hypothetical “democracy” of diseases potentially affecting everyone has to be retracted when analyzing real-world data. We must acknowledge that, actually, nothing is fair about diseases. Access to medical care, nutrition, socioeconomic status, and education are relevant factors in determining course and outcome of many diseases, especially in the vascular area. Stroke follows this rule: As compared to White people, other underrepresented racial-ethnic populations are featured by a disproportionately higher prevalence of traditional vascular risk factors (hypertension, diabetes, obesity above all).
Besides socioeconomic and cultural determinants of lifestyle resulting in vascular risk factors, Kamin Mukaz et al. explored genetic and biological factors partly accounting for the racial disparity of stroke by reviewing current evidence from large cohorts.