Elena Zapata-Arriaza, MD PhD
Thirugnanachandran T, Beare R, Mitchell M, Wong C, Vuong J, Singhal S, Slater LA, Hilton J, Sinnott M, Srikanth V, et al. Anterior Cerebral Artery Stroke: Role of Collateral Systems on Infarct Topography. Stroke. 2021.
Anterior cerebral artery (ACA) stroke is less frequent when compared with middle cerebral artery (MCA) occlusion, and consequently, mechanical thrombectomies, perfusion studies, pial collateral system or clinical consequences based on the topography of the lesion are less known. With the aim of evaluating the role of the circle of Willis (CoW) and leptomeningeal anastomoses (LA) in modifying regional variation in infarct topography following occlusion of the anterior cerebral artery and its branches, Thirugnanachandran and colleagues employed voxel-based imaging in conjunction with computer model of cerebral circulation to understand the temporal and spatial evolution of the topography of ACA stroke following vessel occlusion. The experiments included occlusion of successive branches of the anterior cerebral artery while the configurations of the CoW were varied.