Author Interview: Prof. Dr. Matthias Endres on “Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke”
A conversation with Prof. Dr. Matthias Endres, MD, Director of the Department of Neurology, Charité-Universitätsmedizin, Berlin, Germany, on neuro-immune crosstalk in ischemic stroke.
Interviewed by Dr. Aurora Semerano, MD, Stroke Neurologist, San Raffaele Hospital, Milan, Italy (@semerano_aurora).
They will be discussing the article “Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke,” published in the April 15, 2022 issue of Circulation Research.
Dr. Semerano: Your article is part of a Compendium on Stroke and Neurocognitive Impairment published in Circulation Research, which includes several contributions about the advances made over the past five years in different fields of stroke research that were not addressed in the previous compendium. Which are, in your opinion, the most relevant advances in stroke immunology in these last five years?
Prof. Dr. Endres: First of all, thanks for including me in your blog, and thank you for very elaborate questions. Many of them would require a long answer, but I will try to be brief and refer interested readers to our review article instead.
Regarding the most important advances of the last five years — this is not an easy question. With regard to etiology and stroke risk, I think that recent large-scale genetic studies have led to a huge step forward to identify novel loci associated with stroke risk that can also be targeted pharmacologically. Personally, I find the work on clonal hematopoeisis and association with vascular and stroke risk very interesting. Regarding the acute phase of stroke, there are quite a number of high-quality publications on the complex role of the different players (i.e., neutrophils, monocytes, microglia, as well as T and B cells) in the ischemic cascade in the brain. Lastly, there is now a strong link between immune pathways following stroke and the development of post-stroke dementia (and also depression).