Article Commentary: “Sex Differences in Presentation of Stroke: A Systematic Review and Meta-Analysis”
Farah Aleisa, MD
Ali M, van Os HJA, van der Weerd N, Schoones JW, Heymans MW, Kruyt ND, Visser MC, Wermer MJH. Sex Differences in Presentation of Stroke: A Systematic Review and Meta-Analysis. Stroke. 2021.
In the literature, women do worse after stroke than men, mortality and severe stroke are higher among women, and atypical clinical presentation of acute stroke could explain the higher rate of misdiagnosis in women. Interestingly, a previous cohort study indicated that women who presented with a transient ischemic attack (TIA) or minor stroke more frequently received a diagnosis of stroke mimic compared with men with similar symptomatology; at the same time, stroke recurrence rate within 90 days of stroke onset were similar in both men and women, raising the possibility of sex biases in diagnosing acute stroke. Here, we will go through a systematic analysis of different acute stroke presentations between men and women.