Antithrombotic Therapy Associated With Mild Severity of Ischemic Stroke in Patients With Atrial Fibrillation
Ying Gue, PhD
Jung YH, Kim YD, Kim J, Han SW, Oh MS, Lee JS, Lee K-Y. Initial Stroke Severity in Patients With Atrial Fibrillation According to Antithrombotic Therapy Before Ischemic Stroke. Stroke. 2020;51:2733–2741.
The use of oral anticoagulants (OAC) has been shown to reduce the incidence of stroke in patients with atrial fibrillation (AF). Apart from a study in 2006,1 there has not been any contemporary data exploring the association of OAC and stroke severity.
This study explores 10 years’ worth of data from a multicenter stroke registry in Korea investigating severity of acute ischemic stroke (AIS) and its relation to antithrombotic use (divided into none vs. antiplatelets vs. OAC) in patients with a history of AF. Out of a total of 77579 patients in the database, 6786 had a diagnosis of AF prior to their presentation with AIS. 2304 were not on antithrombotics, 2701 were on antiplatelets, and 1781 were on OAC.