Can Women With Cerebral and Spinal Cavernous Malformations Safely Get Pregnant?
Muhammad Rizwan Husain, MD
Joseph NK, Kumar S, Brown Jr. RD, Lanzino G, Flemming KD. Influence of Pregnancy on Hemorrhage Risk in Women With Cerebral and Spinal Cavernous Malformations. Stroke. 2021;52:434–441.
In this entry, I discuss the publication by Nycole K. Joseph and colleagues regarding pregnancy and hemorrhagic risk with known cerebral and spinal cavernous malformations (CM). Previous studies have reported a hemorrhage risk as high as 11% in pregnant women with CM. However, those studies assumed that CM are congenital lesions, present throughout life, and that they contain both estrogen and progesterone receptors leading to their enlargement and potential rupture during pregnancy. However, over time, it has been demonstrated that CM are both acquired lesions and that they do not have, what was initially thought, the estrogen and progesterone receptors. The authors here have attempted to demonstrate how pregnancy influences the risk of hemorrhage in women of child-bearing age both in the pregnant and non-pregnant state, and included only those women with a known diagnosis of cerebral or spinal CM.