Rachel Forman, MD
The topic of heart failure (HF) is not uncommon in the stroke world. It is a known risk factor for stroke and is related to prothrombotic/proinflammatory states, worsening of cerebral tissue oxygenation, and hemodynamic impairment. There is also consideration if HF may affect the safety and efficacy of acute stroke therapies. Some concerns include reduced circulation after tPA with low cardiac output or difficulties with anesthesia management during MT. This study by Siedler et al. aimed to look at the effects of HF on stroke patients who received tPA, mechanical thrombectomy (MT), or both. The authors note the importance of this study and that many of the prospective clinical trials have excluded HF patients.
Patients who received tPA or MT at a university stroke center were included into a prospective registry. Patients with HF were identified based on their echocardiograms (transthoracic or transesophageal) done as a part of the stroke evaluation. The impairment of left ventricular ejection fraction (LVEF) was categorized as mild if >35% EF, moderate if 25-35% EF, and severe if <25% EF. Functional outcome was assessed after 90 days by telephone interviews and favorable outcome was considered mRS 0-2.