Akarolo-Anthony SN, Jiménez MC, Chiuve SE, Spiegelman D, Willett WC, and Rexrode KM. Plasma Magnesium and Risk of Ischemic Stroke Among Women. Stroke. 2014
A total of 459 confirmed stroke cases and 459 controls had magnesium levels for analyses and this was divided into two main groups to differentiate between what can be considered “low” levels and normal levels as follows- (<0.82 mmol/l versus >0.82 mmol/l). Magnesium levels were measured by colorimetric assay on Hitachi 917 analyzer and tests of significance were conducted using Mantel-Haenszel and Fisher’s exact tests. With regards to the association between plasma magnesium and the risk of total ischemic stroke, the relative risk and 95% confidence interval for the lowest quintile compared to the highest quintile was 1.34 (0.86-2.10), p-trend 0.13. Women in the lowest quintile of plasma magnesium were most likely to be current smokers, use thiazide diuretics, post-menopausal hormone therapy, have hypertension and diabetes, and consume more alcohol with median plasma magnesium levels in the lowest and highest quintiles being 0.78 mmol/l and 0.95 mmol/l respectively. Of note, the median magnesium levels (0.86 mmol/l) did not differ between ischemic stroke cases and controls.