It is not clear how to interpret the efficacy of these compounds, and more in vivo data is required prior to moving forward with clinical trials. The authors point out that there are limited measures to reduce bias, which compromises the internal validity of the results (e.g. randomization or blinding). Studies with the fewest measures to reduce bias had the largest effects reported. It was surprising to learn that four interventions actually improved neurobehavioral outcomes and infarct size, however none have been tested clinically yet, which may be appropriate as more animal data needs to be collected. The SHRSP may be a good animal model to study lacunar stroke, but it is still not certain that the pathophysiology is similar to that in humans. Hopefully there will be translation of some of these compounds to patients in clinical trials, as we learn more from these animal models.
Animal interventions in lacunar stroke, clinical trials down the pipeline
It is not clear how to interpret the efficacy of these compounds, and more in vivo data is required prior to moving forward with clinical trials. The authors point out that there are limited measures to reduce bias, which compromises the internal validity of the results (e.g. randomization or blinding). Studies with the fewest measures to reduce bias had the largest effects reported. It was surprising to learn that four interventions actually improved neurobehavioral outcomes and infarct size, however none have been tested clinically yet, which may be appropriate as more animal data needs to be collected. The SHRSP may be a good animal model to study lacunar stroke, but it is still not certain that the pathophysiology is similar to that in humans. Hopefully there will be translation of some of these compounds to patients in clinical trials, as we learn more from these animal models.
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