Framingham Stroke Risk Score and Cognitive Impairment for Predicting First-Time Stroke in the Oldest Old. Stroke. 2013
The relationship between cognitive impairment and increased risk of stroke has been established in earlier large studies. This was the first study to reproduce these findings in the oldest old population, a population that is on the rise in developed countries, and hence of growing public health importance. The drawback of this study is the lack of neuroimaging, rendering the authors unable to identify type of stroke and silent strokes, which would affect risk of recurrent stroke. Also, the MMSE is not ideal to evaluate cognitive impairment due to vascular causes, unlike the Montral Cognitive Assessment (MoCA). Nevertheless, this study builds the case that cognitive impairment is a tool for predicting stroke risk in not only the younger old, but the oldest old as well.