Cerebral Microbleeds: A Risk Factor for Intracranial Hemorrhage and Worse Outcomes After Thrombolytic Therapy for Acute Ischemic Stroke
Mark R. Etherton, MD PhD
Charidimou A, Turc G, Oppenheim C, Yan S, Scheitz JF, Erdur H, et al. Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Stroke Thrombolysis: Individual Patient Data Meta-Analysis. Stroke. 2017
In this entry, I discuss the recent meta-analysis, using individual patient data, by Andreas Charidimou and colleagues on cerebral microbleeds (CMB) and the risk of intracerebral hemorrhage (ICH) and poor functional outcomes after intravenous thrombolytic therapy for acute ischemic stroke.
Prior to this study, a recent meta-analysis had demonstrated that the mere presence of pre-treatment CMBs was associated with increased odds of symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolytic therapy for acute ischemic stroke (Charidimou et al. Stroke. 2015). Building on this study, the authors performed a pooled, individual patient data meta-analysis to evaluate several hypotheses pertaining to the presence, quantity, and location of pre-treatment CMBs in relation to ICH risk and post-stroke outcomes.